SCIENCE / REAL-WORLD EVIDENCE

Appetite Control, Weight Loss, and Muscle Preservation

1-month real-world-evidence study (n=80) lead by Chris D’Adamo, PhD, University of Maryland. 80 overweight American adults took Carb Fence, powered by SiPore®, 3× daily for 1 month, with their normal diet and activity.

A hand holding a SIGRID Carb Fence sachet in a sunlit kitchen

Source: U.S. Real-World Evidence Study, 2025 (N=80)

REAL-WORLD EVIDENCE
WEIGHT & BODY COMPOSITION

62% of participants lost weight in just 4 weeks.

Average weight loss among responders: 4.2 lbs, preserving muscle mass. Results with normal diet and activity.

62%lost weight
4.2 lbsavg loss among responders
Preservedmuscle mass
APPETITE & CRAVINGS IMPROVEMENT

Significant reductions reported by participants.

Satiety was surveyed at the start and at the end of the month.

↓19%hunger
↓30%snacking
↓25%sugar cravings
COMPLIANCE & SAFETY

Excellent tolerability.

95%daily compliance
0serious adverse events
Excellenttolerability
STUDY DESIGN

One month of everyday use, measured daily.

The study followed adults in their normal routines, without changes to diet or activity.

80 overweight American adults Carb Fence, 3× daily for 1 month Body composition scale: daily measure Satiety survey at start and end

Real-world evidence is observational: it shows what is observed in everyday use, not the results of a controlled clinical trial.

A SIGRID Carb Fence sachet on a kitchen table
STUDY LEAD

Led by Chris D’Adamo, PhD.

University of Maryland. 100+ peer-reviewed publications. Expert in nutrition and lifestyle medicine.

Chris D’Adamo, PhD

Chris D’Adamo

PhD, University of Maryland

One part of a broader evidence program.

Real-world evidence adds what is observed in everyday use to SiPore®’s controlled clinical studies, consumer research and preclinical science.