SCIENCE

From scientific insight to human evidence.

SiPore® has been developed through more than 15 years of research, progressing from fundamental and preclinical investigation into human clinical evaluation. The research program explores how precisely engineered porous silica can influence digestion, how SiPore® performs in controlled human studies, what is observed in real-world use, and how the technology is tolerated.

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15+ years of SiPore® research.

SiPore® has progressed from early mechanism and preclinical research into controlled human studies, larger-scale clinical validation and evidence from real-world and consumer settings.

15+YEARS OF RESEARCH

6CLINICAL TRIALS 9PEER-REVIEWED PUBLICATIONS 10+GRANTED PATENTS

A BROAD EVIDENCE PROGRAM

Robust Validation of SiPore®

SiPore®’s evidence base includes preclinical research, controlled human studies, real-world evidence and consumer research.

PRECLINICAL RESEARCHHow does the technology work?Research into engineered pore structure, digestive-enzyme entrapment, carbohydrate and fat digestion, and the underlying mechanism.Explore CLINICAL STUDIESWhat happens under controlled human study conditions?Human studies evaluating SiPore® and SiPore®-powered interventions under defined research protocols.Explore REAL-WORLD EVIDENCEWhat is observed outside a traditional randomized trial?Evidence generated through use in real-world settings and populations.Explore CONSUMER STUDIESWhat do people report experiencing?Structured consumer feedback exploring experiences reported while using SiPore®-powered products.Explore

MORE THAN 15 YEARS OF RESEARCH

Built step by step.

SiPore® did not begin as a finished consumer product. The technology grew out of scientific work investigating how precisely controlled porous materials could interact with digestion. Over more than 15 years, the research program has progressed through fundamental investigation, preclinical research and human clinical evaluation.

SCIENTIFIC ORIGINInvestigating engineered porous silica and its potential interaction with digestive processes.
MECHANISM RESEARCHUnderstanding pore structure, digestive-enzyme entrapment and effects on carbohydrate and fat digestion.
FIRST HUMAN STUDIESMoving from preclinical research into human evaluation.
EXPANDING CLINICAL PROGRAMControlled studies evaluating metabolic outcomes and safety/tolerability.
LARGE-SCALE CLINICAL RESEARCHIncluding the SHINE randomized clinical trial.
REAL-WORLD & CONSUMER EVIDENCEExtending understanding beyond controlled trials.

FEATURED CLINICAL RESEARCH

CLINICAL

The SHINE Trial

SHINE was a large randomized, double-blind, placebo-controlled, multicenter clinical trial evaluating engineered mesoporous silica particles in individuals with overweight or obesity and prediabetes or newly diagnosed type 2 diabetes. The study was published in eClinicalMedicine, a Lancet Discovery Science journal.

PARTICIPANTS: 318
WEEKS: 12
CLINICAL SITES: 27
PUBLICATION: 2026

Baek J, et al. Effect of Engineered Mesoporous Silica Particles with Tailored Pore Size on Glycaemic Control in Individuals with Prediabetes or Type 2 Diabetes: SHINE Trial. eClinicalMedicine. 2026;97:104042.

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Illustration: a SiPore® particle entraps a portion of the digestive enzymes amylase and lipase

MECHANISM RESEARCH

Science at the level of digestion.

SiPore®’s mechanism is based on precisely engineered porous silica particles. Evidence from preclinical research has been used to investigate how those pores interact with digestive enzymes such as amylase and lipase, and how this can influence the breakdown of carbohydrates and fats. The technology is designed to work locally in the gastrointestinal tract rather than entering the bloodstream.

Explore the technology See preclinical research

SAFETY & TOLERABILITY

Studied in people. Generally well tolerated.

Safety and tolerability have been evaluated across the SiPore® research program. Across human research, SiPore® has been generally well tolerated. SiPore® also has a distinctive local mode of action: the technology works in the gastrointestinal tract and does not enter the bloodstream.

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Simplified gut-local illustration: SiPore® stays in the gastrointestinal tract

PEER-REVIEWED SCIENCE

Read the research.

Explore the peer-reviewed publications contributing to the scientific development and evaluation of SiPore® Technology. Featured publications

2026 · CLINICAL RESEARCH

Effect of Engineered Mesoporous Silica Particles with Tailored Pore Size on Glycaemic Control in Individuals with Prediabetes or Type 2 Diabetes: SHINE Trial

Baek J, et al. · eClinicalMedicine 97:104042

Read the paper

2022 · CLINICAL RESEARCH

Engineered Mesoporous Silica Reduces Long-Term Blood Glucose, HbA1c, and Improves Metabolic Parameters in Prediabetics

Baek J, et al. · Nanomedicine 17(1):9–22

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2020 · CLINICAL RESEARCH

Oral Intake of Mesoporous Silica Is Safe and Well Tolerated in Male Humans

Hagman E, et al. · PLOS ONE 15(10):e0240030

View publication

View all 9 peer-reviewed publications

Questions about the science?

What is SiPore®?

SiPore® is a patented technology based on precisely engineered porous silica particles, designed to work locally during digestion.

How does SiPore® work?

Its engineered pores entrap a portion of digestive enzymes involved in breaking down carbohydrates and fats, slowing digestion so energy from the meal enters the system more gradually.

Does SiPore® enter the bloodstream?

No. SiPore® works locally in the gastrointestinal tract.

Has SiPore® been studied in people?

Yes. The SiPore® research program includes human clinical evaluation, including placebo-controlled studies.

How has SiPore® been tolerated?

Across human research, SiPore® has been generally well tolerated.

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Scientific counsel

Scientific Advisory Board.

Leading clinicians and researchers in metabolism, obesity and drug delivery advising SiPore®'s science.

Precision science for the modern meal.

From engineered pore structure to human clinical evaluation, SiPore® has been developed through more than 15 years of research focused on one central opportunity: Changing how the meal is processed during digestion.

Explore Research & Evidence See how SiPore® works