Research
Research documents
Research papers you can read right here — every one with its licence, a link to the original and a Markdown version for AI assistants.
- Research paperOpen access · CC BY 4.0
Effect of engineered mesoporous silica particles with tailored pore size on glycaemic control in individuals with prediabetes or type 2 diabetes: a randomised, double-blind, placebo-controlled SHINE trial
Jeanha Baek, Anna Ioannidou, Melissa L. Borg, Ghislaine Robert-Nicoud, Kirsi H. Pietiläinen, Stephan Rössner, Eric V. Johnston, Tore Bengtsson
eClinicalMedicine · 2026;97:104042 · published 2 July 2026 · DOI 10.1016/j.eclinm.2026.104042
SiPore21 is an oral gel containing engineered mesoporous silica particles that act locally in the gut by entrapping digestive enzymes and modulating macronutrient uptake. This 12-week, randomised, double-blind, placebo-controlled, multicentre trial was conducted at 27 centres across three European countries; 318 participants were enrolled and assessed, and 312 completed the intervention. SiPore21 significantly reduce