---
title: "U.S. Real-World Evidence Study"
description: "A 1-month real-world-evidence study (N=80) led by Chris D’Adamo, PhD, University of Maryland: appetite control, weight loss and muscle preservation in overweight American adults using Carb Fence, powered by SiPore®."
url: "https://sipore.com/science/us-real-world-evidence-study"
canonical: "https://sipore.com/science/us-real-world-evidence-study"
markdown_url: "https://sipore.com/science/us-real-world-evidence-study.md"
site: "SiPore"
publisher: "SiPore Technologies (Sigrid Therapeutics AB)"
language: "en"
updated: "2026-10-02"
---

# U.S. Real-World Evidence Study

> A 1-month real-world-evidence study (N=80) led by Chris D’Adamo, PhD, University of Maryland: appetite control, weight loss and muscle preservation in overweight American adults using Carb Fence, powered by SiPore®.

*SCIENCE / REAL-WORLD EVIDENCE*

## Appetite Control, Weight Loss, and Muscle Preservation

1-month real-world-evidence study (n=80) lead by Chris D’Adamo, PhD, University of Maryland.

80 overweight American adults took Carb Fence, powered by SiPore®, 3× daily for 1 month, with their normal diet and activity.

Source: U.S. Real-World Evidence Study, 2025 (N=80)

[Download the study summary →](https://sipore.com/static/docs/us-rwe-study-2025.pdf)

[All research & evidence →](https://sipore.com/science/research-evidence#real-world)

*WEIGHT & BODY COMPOSITION*

### 62% of participants lost weight in just 4 weeks.

Average weight loss among responders: 4.2 lbs, preserving muscle mass.

Results with normal diet and activity.

- 62% — lost weight
- 4.2 lbs — avg loss among responders
- Preserved — muscle mass

*APPETITE & CRAVINGS IMPROVEMENT*

### Significant reductions reported by participants.

Satiety was surveyed at the start and at the end of the month.

- ↓19% — hunger
- ↓30% — snacking
- ↓25% — sugar cravings

*COMPLIANCE & SAFETY*

### Excellent tolerability.

- 95% — daily compliance
- 0 — serious adverse events
- Excellent — tolerability

*STUDY DESIGN*

### One month of everyday use, measured daily.

The study followed adults in their normal routines, without changes to diet or activity.

Real-world evidence is observational: it shows what is observed in everyday use, not the results of a controlled clinical trial.

- 80 overweight American adults
- Carb Fence 3× daily for 1 month
- Body composition scale: daily measure
- Satiety survey at start and end

[Download the study summary (PDF) →](https://sipore.com/static/docs/us-rwe-study-2025.pdf)

*STUDY LEAD*

### Led by Chris D’Adamo, PhD.

University of Maryland. 100+ peer-reviewed publications. Expert in nutrition and lifestyle medicine.

- Chris D’Adamo

### One part of a broader evidence program.

Real-world evidence adds what is observed in everyday use to SiPore®’s controlled clinical studies, consumer research and preclinical science.

[Explore Research & Evidence →](https://sipore.com/science/research-evidence)

[Download the study summary →](https://sipore.com/static/docs/us-rwe-study-2025.pdf)

## How to cite

SiPore Technologies (Sigrid Therapeutics AB). “U.S. Real-World Evidence Study”. SiPore, 2026-10-02. https://sipore.com/science/us-real-world-evidence-study (accessed <date>).

Use the trademarks as written: SiPore®, Carb Fence™. For the SHINE trial, cite the peer-reviewed publication in *eClinicalMedicine* (The Lancet Discovery Science, 2026) rather than this page.

## Company & contact

- **Company:** SiPore Technologies — legal entity Sigrid Therapeutics AB (Swedish org.nr [556958-3023](https://www.allabolag.se/foretag/sigrid-therapeutics-ab/sundbyberg/forskning/2K3ZHRJI5YE3M))
- **Stockholm headquarters:** Vasagatan 14A, 172 61 Sundbyberg, Sweden ([map](https://www.google.com/maps/search/?api=1&query=Vasagatan%2014A%2C%20172%2061%20Sundbyberg%2C%20Sweden))
- **General enquiries:** [contact@sipore.com](mailto:contact@sipore.com)
- **Partnerships & licensing:** [partnerships@sipore.com](mailto:partnerships@sipore.com)
- **Origin:** Founded in Stockholm, Sweden
- **Taglines:** “The meal companion for modern food.” · “Same meal. Less impact.” · “Scandinavian science. Global impact.” · “Precision science for the modern meal.”
- **About:** SiPore® is a patented meal-companion technology designed to reduce the impact of modern meals at the level of digestion.

**Our sites** — all sites owned and operated by Sigrid Therapeutics AB:

- [SiPore.com](https://www.sipore.com/): Technology, science & partnerships
- [SiPorePro.com](https://www.siporepro.com/): Practitioner products & professional resources
- [SigridLife.com](https://sigridlife.com/): SIGRID consumer products
- [SigridStabiliser.se](https://sigridstabiliser.se/): SIGRID Sweden

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