--- title: "Science" description: "The scientific authority for SiPore® Technology: more than 15 years of research, 6 clinical trials, 9 peer-reviewed publications and 10+ granted patents." url: "https://sipore.com/science" canonical: "https://sipore.com/science" markdown_url: "https://sipore.com/science.md" site: "SiPore" publisher: "SiPore Technologies (Sigrid Therapeutics AB)" language: "en" updated: "2026-10-05" --- # Science > The scientific authority for SiPore® Technology: more than 15 years of research, 6 clinical trials, 9 peer-reviewed publications and 10+ granted patents. _SCIENCE_ ## From scientific insight to human evidence. SiPore® has been developed through more than 15 years of research, progressing from fundamental and preclinical investigation into human clinical evaluation. The research program explores how precisely engineered porous silica can influence digestion, how SiPore® performs in controlled human studies, what is observed in real-world use, and how the technology is tolerated. [View publications](https://sipore.com/science/publications) ![From scientific insight to human evidence.](https://sipore.com/media/mup26t2l-5a6bkjm6.webp) ## 15+ years of SiPore® research. SiPore® has progressed from early mechanism and preclinical research into controlled human studies, larger-scale clinical validation and evidence from real-world and consumer settings. - 15+ — YEARS OF RESEARCH - 6 — CLINICAL TRIALS - 9 — PEER-REVIEWED PUBLICATIONS - 10+ — GRANTED PATENTS *A BROAD EVIDENCE PROGRAM* ## Robust Clinical Validation of SiPore® SiPore®’s evidence base includes preclinical research, controlled human studies, real-world evidence and consumer research. Each contributes something different, and each should be understood according to what that evidence can actually show. - How does the technology work? — Research into engineered pore structure, digestive-enzyme entrapment, carbohydrate and fat digestion, and the underlying mechanism. - What happens under controlled human study conditions? — Human studies evaluating SiPore® and SiPore®-powered interventions under defined research protocols. - What is observed outside a traditional randomized trial? — Evidence generated through use in real-world settings and populations. - What do people report experiencing? — Structured consumer feedback exploring experiences reported while using SiPore®-powered products. *MORE THAN 15 YEARS OF RESEARCH* ## Built step by step. SiPore® did not begin as a finished consumer product. The technology grew out of scientific work investigating how precisely controlled porous materials could interact with digestion. Over more than 15 years, the research program has progressed through fundamental investigation, preclinical research and human clinical evaluation. - SCIENTIFIC ORIGIN — Investigating engineered porous silica and its potential interaction with digestive processes. - MECHANISM RESEARCH — Understanding pore structure, digestive-enzyme entrapment and effects on carbohydrate and fat digestion. - FIRST HUMAN STUDIES — Moving from preclinical research into human evaluation. - EXPANDING CLINICAL PROGRAM — Controlled studies evaluating metabolic outcomes and safety/tolerability. - LARGE-SCALE CLINICAL RESEARCH — Including the SHINE randomized clinical trial. - REAL-WORLD & CONSUMER EVIDENCE — Extending understanding beyond controlled trials. *FEATURED CLINICAL RESEARCH* SHINE was a large randomized, double-blind, placebo-controlled, multicenter clinical trial evaluating engineered mesoporous silica particles in individuals with overweight or obesity and prediabetes or newly diagnosed type 2 diabetes. The study was published in eClinicalMedicine, a Lancet Discovery Science journal. ### The SHINE Trial [Explore the clinical evidence →](https://sipore.com/science/research-evidence#clinical) *MECHANISM RESEARCH* ## Science at the level of digestion. SiPore®’s mechanism is based on precisely engineered porous silica particles. Evidence from preclinical research has been used to investigate how those pores interact with digestive enzymes such as amylase and lipase, and how this can influence the breakdown of carbohydrates and fats. The technology is designed to work locally in the gastrointestinal tract rather than entering the bloodstream. [Explore the technology →](https://sipore.com/technology) [See preclinical research →](https://sipore.com/science/research-evidence#preclinical) *SAFETY & TOLERABILITY* ## Studied in people. Generally well tolerated. Safety and tolerability have been evaluated across the SiPore® research program. Across human research, SiPore® has been generally well tolerated. SiPore® also has a distinctive local mode of action: the technology works in the gastrointestinal tract and does not enter the bloodstream. [Explore Safety & Tolerability →](https://sipore.com/science/safety-tolerability) *PEER-REVIEWED SCIENCE* ## Read the research. Explore the peer-reviewed publications contributing to the scientific development and evaluation of SiPore® Technology. Featured publications - Baek J, et al. **Effect of Engineered Mesoporous Silica Particles with Tailored Pore Size on Glycaemic Control in Individuals with Prediabetes or Type 2 Diabetes: SHINE Trial** eClinicalMedicine 97:104042, 2026 [Read the paper](https://sipore.com/docs/shine-trial) - Baek J, et al. **Engineered Mesoporous Silica Reduces Long-Term Blood Glucose, HbA1c, and Improves Metabolic Parameters in Prediabetics** Nanomedicine 17(1):9–22, 2022 [View publication](https://doi.org/10.2217/nnm-2021-0235) - Hagman E, et al. **Oral Intake of Mesoporous Silica Is Safe and Well Tolerated in Male Humans** PLOS ONE 15(10):e0240030, 2020 [View publication](https://doi.org/10.1371/journal.pone.0240030) [View all 9 peer-reviewed publications →](https://sipore.com/science/publications) ## Questions about the science? ### What is SiPore®? SiPore® is a patented technology based on precisely engineered porous silica particles, designed to work locally during digestion. ### How does SiPore® work? Its engineered pores entrap a portion of digestive enzymes involved in breaking down carbohydrates and fats, slowing digestion so energy from the meal enters the system more gradually. ### Does SiPore® enter the bloodstream? No. SiPore® works locally in the gastrointestinal tract. ### Has SiPore® been studied in people? Yes. The SiPore® research program includes human clinical evaluation, including placebo-controlled studies. ### How has SiPore® been tolerated? Across human research, SiPore® has been generally well tolerated. - Explore the Scientific FAQ → ## Explore the full Science section. - **RESEARCH & EVIDENCE** — What does the research show? — Clinical studies, real-world evidence, consumer research and preclinical science. - **SAFETY & TOLERABILITY** — What do we know about tolerability? — Explore the evidence on gut-local action, human safety and tolerability. - **PUBLICATIONS** — Where can I read the papers? — Browse the peer-reviewed scientific literature behind the SiPore® research program. - **SCIENTIFIC FAQ** — Can I get a clear answer? — Plain-language answers to common scientific and technical questions about SiPore®. *Scientific counsel* ## Scientific Advisory Board. Leading clinicians and researchers in metabolism, obesity and drug delivery advising SiPore®'s science. - Stephan Rössner - Kirsi Pietiläinen - Benjamin Boyd - Jørgen Thorball - Mikael Rydén - Arvo Hanni - Jan Lundberg - Andy Leyland ## Precision science for the modern meal. From engineered pore structure to human clinical evaluation, SiPore® has been developed through more than 15 years of research focused on one central opportunity: **Changing how the meal is processed during digestion.** [Explore Research & Evidence →](https://sipore.com/science/research-evidence) [See how SiPore® works →](https://sipore.com/technology) ## How to cite SiPore Technologies (Sigrid Therapeutics AB). “Science”. SiPore, 2026-10-05. https://sipore.com/science (accessed ). Use the trademarks as written: SiPore®, Carb Fence™. For the SHINE trial, cite the peer-reviewed publication in *eClinicalMedicine* (The Lancet Discovery Science, 2026) rather than this page. ## Company & contact - **Company:** SiPore Technologies — legal entity Sigrid Therapeutics AB (Swedish org.nr [556958-3023](https://www.allabolag.se/foretag/sigrid-therapeutics-ab/sundbyberg/forskning/2K3ZHRJI5YE3M)) - **Stockholm headquarters:** Vasagatan 14A, 172 61 Sundbyberg, Sweden ([map](https://www.google.com/maps/search/?api=1&query=Vasagatan%2014A%2C%20172%2061%20Sundbyberg%2C%20Sweden)) - **General enquiries:** [contact@sipore.com](mailto:contact@sipore.com) - **Partnerships & licensing:** [partnerships@sipore.com](mailto:partnerships@sipore.com) - **Origin:** Founded in Stockholm, Sweden - **Taglines:** “The meal companion for modern food.” · “Same meal. Less impact.” · “Scandinavian science. Global impact.” · “Precision science for the modern meal.” - **About:** SiPore® is a patented meal-companion technology designed to reduce the impact of modern meals at the level of digestion. **Our sites** — all sites owned and operated by Sigrid Therapeutics AB: - [SiPore.com](https://www.sipore.com/): Technology, science & partnerships - [SiPorePro.com](https://www.siporepro.com/): Practitioner products & professional resources - [SigridLife.com](https://sigridlife.com/): SIGRID consumer products - [SigridStabiliser.se](https://sigridstabiliser.se/): SIGRID Sweden --- [View on site](https://sipore.com/science) · [Site index for agents (llms.txt)](https://sipore.com/llms.txt)