# Research documents — SiPore

> Research papers hosted on this site, each with a Markdown version for AI agents. Every document links to its original (version of record) and states its licence.

- [Effect of engineered mesoporous silica particles with tailored pore size on glycaemic control in individuals with prediabetes or type 2 diabetes: a randomised, double-blind, placebo-controlled SHINE trial](https://sipore.com/docs/shine-trial.md): Jeanha Baek et al. · eClinicalMedicine, Volume 97, article 104042, 2026 (published online 2 July 2026) · DOI 10.1016/j.eclinm.2026.104042. SiPore21 is an oral gel containing engineered mesoporous silica particles that act locally in the gut by entrapping digestive enzymes and modulating macronutrient uptake. This 12-week, randomised, double-blind, placebo-controlled, multicentre trial was conducted at 27 centres across three European countries; 318 participants were enrolled and assessed, and 312 completed the intervention. SiPore21  Web page: https://sipore.com/docs/shine-trial · PDF: https://sipore.com/docs/shine-trial.pdf